Generic Synthroid (Levothyroxine)
Synthroid contains substance identical to the thyroid gland hormone and is used to treat hypothyroidism and obesity.
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Product Description

Synthroid tablets contain the active ingredient levothyroxine. Levothyroxine belongs to a small group of medicines called thyroid hormones, which work by replacing the body's low levels of thyroxine.
Synthroid Levothyroxine tablets are used to treat hypothyroidism, a disease in which the thyroid gland is underactive and does not produce enough thyroxine, a hormone, which is important for controlling your metabolism. Symptoms of hypothyroidism include tiredness, muscle weakness, cramps, feeling the cold, a slow heart rate, dry and flaky skin, hair loss, a deep husky voice and weight gain.
Levothyroxine tablets are also used to treat children born with hypothyroidism (congenital), those who develop hypothyroidism in the first year of life (neonatal) and children who have hypothyroidism as part of juvenile myxoedema, a condition in which the amount of thyroxine produced by the body is low.
Ask your doctor if you have any questions about why Levothyroxine tablets have been prescribed for you.
Your doctor may have prescribed Synthroid Levothyroxine tablets for another reason.

Do not take Synthroid Levothyroxine tablets if:

  •  you have had an allergic reaction before to any of the ingredients in Synthroid Levothyroxine tablets listed at the end of this leaflet
  •  you have thyrotoxicosis, a disease in which the thyroid gland is overactive and produces too much thyroxine
  •  the packaging is torn or shows signs of interference, or the tablets look damaged or discoloured.

Do not take it after the expiry date printed on the pack.
If you take it after the expiry date has passed, it may not work as well. If the pharmacist has repacked the medicine for you, there may not be an expiry date on the pack.

Before taking Synthroid Levothyroxine, tell your doctor or pharmacist if:

  • you are allergic to any of the ingredients in Levothyroxine tablets of this leaflet
  • you are allergic to any other medicines, foods, dyes or preservatives
  • you have any other health problems, especially:
  • diabetes
  • heart disease
  • high blood pressure
  • underactive adrenal glands.

Tell your doctor if you are pregnant or plan to become pregnant.
Synthroid Levothyroxine is not thought to be harmful to an unborn baby when taken by a pregnant woman. However, thyroxine levels need to be watched carefully during pregnancy because too much or too little thyroxine in the mother's bloodstream could affect the well-being of an unborn baby.

Also tell your doctor if you are breastfeeding or planning to breastfeed.
Although the active ingredient in Synthroid Levothyroxine tablets, levothyroxine, passes into breast milk, it is not likely to have a harmful effect on a baby. However, it might interfere with the results of tests to detect congenital hypothyroidism in the baby. You should not breastfeed unless your doctor says you can.

Tell your doctor if you are taking any other medicines, including medicines that you buy without a prescription from a pharmacy, supermarket or health food shop. You should tell any health professional who is prescribing a new medicine for you that you are taking Synthroid Levothyroxine tablets.
Some medicines may interfere with Synthroid Levothyroxine tablets. These include:

  • anticoagulants, medicines used to thin your blood and treat blood clots
  • medicines for epilepsy (e.g. phenytoin, carbamazepine)
  • medicines used to treat depression
  • cardiac glycosides, for example digoxin (LanoxinTM), used to treat heart problems
  • medicines used to lower blood cholesterol levels such as statins (e.g. simvastatin, lovastatin), bile acid sequestrants (e.g. colestipol), cholestyramine (Questran), and clofibrate
  • androgens (male hormones) and anabolic steroids (body building hormones)
  • antacids (medicines used to treat heartburn and indigestion), such as aluminium hydroxide
  • cation exchange resins, e.g. Kayexalate
  • sucralfate, used to treat ulcers
  • calcium carbonate and ferrous sulphate
  • tamoxifen, imatinib and 5-fluorouracil, used to treat certain types of cancer
  • methadone, used to treat pain
  • amiodarone, a medicine used to treat irregular heart beat
  • medicines to relieve asthma attacks
  • medicines used for weight reduction
  • the oral contraceptive pill.

These medicines may be affected by Synthroid Levothyroxine tablets, or may affect how well it works. You may need different amounts of your medicine, or you may need to take different medicines.
Your doctor or pharmacist has more information on medicines to be careful with or to avoid while taking Synthroid Levothyroxine tablets.

HOW TO TAKE Synthroid Levothyroxine TABLETS
How much to take
Take Synthroid Levothyroxine tablets exactly as your doctor has prescribed.
Your doctor will tell you how many Synthroid Levothyroxine tablets to take each day. Your doctor will calculate the dose based on your weight.
Never take more tablets than your doctor has prescribed.
Your doctor may vary your dose depending on how you respond to Synthroid Levothyroxine
In adults, the usual dose is 50 microgram to 100 microgram daily, increased every 4 to 6 weeks as needed. The maximum dose is 200 microgram daily.
The dose in children is reduced according to their weight and age.
Elderly people usually need a smaller dose because they are more sensitive to the effects of levothyroxine.
Your doctor will do regular blood tests to make sure levothyroxine is working for you.

How to take it
Swallow tablets whole with a glass of water.
Tablets should be taken on an empty stomach, preferably at least 30 minutes before breakfast.

How long to take it
Many people need treatment with Synthroid Levothyroxine tablets long term.

If you forget to take it
Do not take an extra dose. Wait until the next dose and take your normal dose then.

Do not try to make up for the dose that you missed by taking more than one dose at a time.

WHILE YOU ARE TAKING Synthroid Levothyroxine TABLETS
Things you must do
Tell all doctors and pharmacists involved in your healthcare that you are taking Synthroid Levothyroxine tablets.
If you are about to be started on any new medicine, tell your doctor and pharmacist that you are taking Synthroid Levothyroxine tablets.
Tell your doctor if you are pregnant or planning to become pregnant or are breastfeeding while taking Synthroid Levo-thyroxine tablets.
Tell your doctor if, for any reason, you have not taken Synthroid Levo-thyroxine tablets exactly as prescribed.
Otherwise, your doctor may think it is not working for you and change your Synthroid Levo-thyroxine tablets dose unnecessarily.
Tell your doctor if you feel that Synthroid Levo-thyroxine tablets are not helping your condition.

Things you must not do
Do not stop taking Synthroid Levo-thyroxine tablets or change the dose without first checking with your doctor, or your symptoms could return.
Do not let yourself run out of medicine over the weekend or on holidays.
Do not give Synthroid Levothyroxine tablets to anyone else, even if they have the same condition as you.
Do not take any other medicines, whether they require a prescription or not, without first asking your doctor or a pharmacist.

Things to be careful of
Do not drive or operate machinery until you know how your Synthroid Levothyroxine tablets dose is affecting you.

Immediately telephone your doctor, or go to Accident and Emergency at your nearest hospital, if you think that you or anyone else may have taken too much Synthroid Levothyroxine tablets.
Do this even if there are no signs of discomfort or poisoning.
You may need urgent medical attention.
Keep phone numbers for these places handy.
An overdose of Synthroid Levothyroxine tablets can cause agitation, confusion, irritability, hyperactivity, sweating, headaches, fever, widened pupils, fits, palpitations and diarrhoea.

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Synthroid Levothyroxine tablets.
All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
TELL YOUR DOCTOR IMMEDIATELY if you think you are having an allergic (hypersensitivity) reaction to Synthroid Levothyroxine tablets.
Symptoms include:

  • severe skin rash, itching or hives
  • swelling of the face, lips, mouth or throat
  • difficulty breathing or swallowing
  • fever
  • low blood pressure (feeling faint or dizzy).

However, these symptoms do not necessarily mean that you are allergic to Synthroid Levothyroxine tablets.

Tell your doctor if you notice any of the following:

  • diarrhoea
  • nausea
  • vomiting
  • irregular or fast heart beat
  • chest pain
  • sweating, flushing
  • weight loss
  • muscle weakness/cramps, tremors
  • rapid breathing
  • fever
  • constantly feeling hungry
  • abdominal pain
  • headache
  • inability to sleep
  • feeling restless/excited
  • hair loss
  • irregular period in women
  • Intolerance to heat
  • difficulty in conceiving (carrying a child).

The above side effects are rare and usually mean that your daily Synthroid Levothyroxine tablets dose is too high.

Children taking Synthroid Levothyroxine tablets may experience partial loss of hair during the first few months of therapy, but this effect is usually temporary and subsequent regrowth usually occurs.
Tell your doctor if you notice any other effects.
Other adverse effects not listed above may also occur in some patients.
Do not be alarmed by this list of possible adverse effects.
You may not experience any of them.

Keep your tablets in the blisters until it is time to take them.
If you take the tablets out of the blisters they may not keep well.
Keep Synthroid Levothyroxine tablets in a cool dry place away from light where the temperature stays below 77 F (25°C).
Do not store Synthroid Levothyroxine tablets or any other medicine in a bathroom or near a sink.
Do not leave it in a car or on a window sill.
Heat and dampness can destroy some medicines.
Keep Synthroid Levothyroxine tablets where young children cannot reach it.
A locked cupboard at least one and a half meters above the ground is a good place to store medicines.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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